Phosphoric Acid → HCID 88841051, compound

Participants

Reaction Steps

A solution of 68% potassium thiazole-4-thiocarboxylate (5.4 g., 0.02 mole) in 100 ml. water was washed with 100 ml. of ether and then 200 ml. of pH 6.4 phosphate buffer and 7-aminocephalosporanic acid (5.5 g., 0.02 mole) was added. The mixture was heated at 48° for 4 hours as the pH was kept at 6.4 with NaHCO3 solution. The solution was then cooled and acidified with 40% H3PO4 to pH 5.2. The product was collected by filtration, washed with water and acetone, and air dried overnight to yield 3.0 g. The material was not further purified and IR and NMR spectra were consistent with required structure.

Provenance & Evidence