Phosphoric Acid → HCID 88840609, compound

Participants

Reaction Steps

To a stirred solution of 8.95 g. (0.0328 moles) of 7-aminocephalosporanic acid and 2.76 g. (0.0328 moles) of sodium bicarbonate in 150 ml. of aqueous phosphate buffer at pH 6.4 was added 6.0 g. (0.0328 moles) of thiazole-5-thiocarboxylic acid potassium salt. The mixture was stirred in a nitrogen atmosphere at 50° for 5 hours keeping the pH at 6.6 with 42% phosphoric acid. The mixture was cooled to 20° and the precipitated solid was removed by filtration, washed with water, acetone and ether and dried in vacuo over phosphorus pentoxide to provide 4.25 g. (36%) of a tan crystalline solid. Infrared and NMR spectra were consistent with the structure.

Provenance & Evidence