Phosphoric Acid → HCID 88839701, compound

Participants

Reaction Steps

To a stirred suspension of 6.8 g. (0.025 mole) of 7-aminocephalosporanic acid and 2.1g. (0.025 mole) of sodium bicarbonate in 150 ml. of aqueous phosphate buffer (pH 6.4) was added 4.92 g. (0.025 mole) of 2-methylthiazole-4-thiolcarboxylic acid potassium salt. The mixture was stirred in a nitrogen atmosphere and heated to 50°. The pH was adjusted from 7.0 to 6.5 with 42% phosphoric acid. A tan solid started to precipitate. After 5 hours at 50° the reaction mixture was cooled to 20°. The solid was collected by filtration, washed with water, acetone and ether and dried in vacuo over phosphorous pentoxide to provide 4.5 g. of a tan solid. Yield = 48%. NMR spectrum was consistent with structure.

Provenance & Evidence