Dimethylamine → (1H-Perimidin-2-yl)methyl dimethylcarbamate

Participants

Reaction Steps

A 10 g (0.44 mole) sample of 1H, 3H-oxazolo[3,4-a]perimidine, 3-one is dissolved in glyme at 30°, and the resulting solution is treated with excess 40% aqueous dimethylamine for 10 min. The mixture is then concentrated, dissolved in CHCl3, washed with water and dried. Further concentration gives an oil which is crystallized from ethyl acetate-cylcohexane and is then recrystallized from the same solvents twice to give the desired product, (2-perimidyl)methyl N,N-dimethylcarbamate, as yellow crystals, m.p. 161°-162° C.

Provenance & Evidence