HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Malonate → (2-Benzyl-1,2,3,4-tetrahydroisoquinolin-1-YL)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Malonate | HCID 7761 | — |
| Reactant | HCID 21506615 | HCID 21506615 | — |
| Reactant | 1-Aminomethyl-2-(3-carbethoxypropyl)-1,2,3,4-tetrahydroisoquinoline | HCID 21506663 | — |
| Reactant | potassium butan-1-olate | HCID 178454393 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | (2-Benzyl-1,2,3,4-tetrahydroisoquinolin-1-YL)methanamine | HCID 12857708 | — |
Reaction Steps
1-aminomethyl-2-(3-carbethoxypropyl)-1,2,3,4-tetrahydroisoquinoline [obtainable by reacting 1-benzamidomethyl-2-(2-chloroethyl)-1,2,3,4-tetrahydroisoquinoline with diethyl malonate in the presence of tert.--C4H9OK in tert.-butanol, saponifying, decarboxylation, and esterification]
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03985881 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-362aadf8c28b4844af62e020a6d8b2e6 |
| Source note | uspto-grants-1976_10 |