Acetic Anhydride → N-[2-(Benzyloxy)-5-(pyridine-2-carbonyl)phenyl]acetamide

Participants

Reaction Steps

A mixture of 10.0 g (32.8 mmol) of 3-amino-4-benzyloxyphenyl 2-pyridyl ketone and 40 ml of acetic anhydride is heated on a steam bath for 1 hour. The reaction is concentrated in vacuo to give a residue which is suspended in water and made basic with 10% NaOH. The aqueous phase is extracted with ether and the dried extracts are evaporated to give 3-acetamido-4-benzyloxyphenyl 2-pyridyl ketone.

Provenance & Evidence