HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosgene → [4-(Benzyloxy)-3-isocyanatophenyl](pyridin-2-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | [3-Amino-4-(benzyloxy)phenyl](pyridin-2-yl)methanone | HCID 53880974 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | [4-(Benzyloxy)-3-isocyanatophenyl](pyridin-2-yl)methanone | HCID 54132362 | — |
Reaction Steps
A stirred solution of 40 g (0.41 mol) of phosgene in 150 ml of toluene is held at 25° C while a mixture of (52.5 mmol) of 3-amino-4-benzyloxyphenyl 2-pyridyl ketone and 300 ml of toluene is added slowly. The mixture is refluxed for 30 minutes and then is concentrated to give 4-benzyloxy-3-isocyanatophenyl 2-pyridyl ketone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03985887 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-94d27eb0169c4cbe86d2c3c9546a141b |
| Source note | uspto-grants-1976_10 |