Benzyl Chloride → HCID 53635052, compound

Participants

Reaction Steps

4-Methoxyphenyl (6-methyl-2-pyridyl) ketone and 4-methoxyphenyl (5-n-butyl-2-pyridyl) ketone are nitrated, cleaved with BBr3, treated with benzyl chloride and reduced according to the procedures of Example 1 to give 3-amino-4-benzyloxyphenyl (6-methyl-2-pyridyl) ketone and 3-amino-4-benzyloxyphenyl (5-n-butyl-2-pyridyl) ketone. These compounds are substituted for 3-amino-4-benzyloxyphenyl 2-pyridyl ketone in Example 2 to give α-(4-hydroxy-3-ureidophenyl)-6-methyl-2-piperidylcarbinol hydrochloride and α-(4-hydroxy-3-ureidophenyl)-5-n-butyl-2-piperidylcarbinol hydrochloride. The analogous methylureido compounds are prepared as described in Example 2.

Provenance & Evidence