HuagongsheHuagongshe Chemistry Print Report · For research reference only
o-Fluorobenzaldehyde → HCID 54216523, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | o-Fluorobenzaldehyde | HCID 67970 | — |
| Reactant | Methyl 3-amino-3-ethoxyprop-2-enoate | HCID 71366473 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 54216523 | HCID 54216523 | 59% |
Reaction Steps
Heating a solution of 6.3 g of 2-fluorobenzaldehyde and 14.5 g of 3-amino-3-ethoxyacrylic acid methyl ester in 50 ml of isopropanol for 8 hours yields 2-amino-4-(2-fluorophenyl)-6-ethoxy-4,5-dihydropyridine-3,5-dicarboxylic acid dimethyl ester of melting point 180° C (isopropanol). Yield: 59% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03985886 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-40db6028bbbd4057bfededa0b9bc76fb |
| Source note | uspto-grants-1976_10 |