2,4-Dichlorobenzaldehyde → HCID 12308273, compound

HRID 1287867Notes

Reaction equation

HRID 1287867 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:3]=1[CH:4]=O.[CH2:11]([O:13][C:14](=[O:21])[CH:15]=[C:16]([NH2:20])[O:17][CH2:18][CH3:19])[CH3:12]>>[CH2:11]([O:13][C:14]([C:15]1[CH:4]([C:3]2[CH:6]=[CH:7][C:8]([Cl:10])=[CH:9][C:2]=2[Cl:1])[CH:15]([C:14]([O:13][CH2:11][CH3:12])=[O:21])[C:16]([O:17][CH2:18][CH3:19])=[N:20][C:16]=1[NH2:20])=[O:21])[CH3:12]

Participants

3

Reactant 2

HCID 134042,4-DichlorobenzaldehydeHCID 278451beta-Aminobeta-ethoxyacrylic acid ethyl ester

Product 1

HCID 12308273HCID 12308273, compoundYield 68%

Procedure

Upon boiling a solution of 8.8 g of 2,4-dichlorobenzaldehyde and 15.9 g of 3-amino-3-ethoxyacrylic acid ethyl ester in 50 ml of alcohol for 6 hours, 2-amino-4-(2,4-dichlorophenyl)-6-ethoxy-4,5-dihydropyridine-3,5-dicarboxylic acid diethyl ester of melting point 98° C (ethyl acetate/ petroleum ether) is obtained. Yield: 68% of theory.

Workup

  1. customfor 6 hours

Sources & evidence

ORD record
ord-96e49360d00b4e90a90ab9176b118f0b
Source dataset
uspto-grants-1976_10
Patent number
US03985886

Reaction notes

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