Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | HCID 14299241 | HCID 14299241 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | HCID 21445368 | HCID 21445368 | — |
Reaction Steps
Following the procedure set forth in Example 1, 2-ethyltetrahydroquinoline is mixed with diethyl ethoxymethylenemalonate and heated to 125° to 130° C. for 2 hours. Polyphosphoric acid is added, and the mixture is heated at 115° C. for 1 hour. The mixture is poured into water, neutralized with 40 percent sodium hydroxide, and the product is isolated and saponified in 10 percent sodium hydroxide solution. The solution is neutralized, and the solid product, 6,7-dihydro-5-ethyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid, is isolated by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US03985882 |
|---|
| Source dataset | uspto-grants-1976_10 |
|---|
| ORD ID | ord-801cfc3106be4b07ab83e2d74efcbfc9 |
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| Source note | uspto-grants-1976_10 |
|---|
