Sodium Hydroxide → Thiourea, (2,3-dihydro-1H-inden-2-yl)-

HRID 1287896Notes

Reaction equation

HRID 1287896 reaction equation
C([NH:9][C:10]([NH:12][CH:13]1[CH2:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14]1)=[S:11])(=O)C1C=CC=CC=1.[OH-].[Na+]>O>[CH2:14]1[C:15]2[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:21][CH:13]1[NH:12][C:10]([NH2:9])=[S:11]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 21507070N-[(2,3-Dihydro-1H-inden-2-yl)carbamothioyl]benzamide

Product 1

HCID 5277341Thiourea, (2,3-dihydro-1H-inden-2-yl)-

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1-Benzoyl-3-(2-indanyl)thiourea (0.931 g.) and sodium hydroxide (0.500 g.) were refluxed in water (6 ml.) for 10 minutes. The mixture was cooled, extracted into chloroform and the chloroform extracts washed with water, dried (MgSO4) and evaporated to give a white solid. Recrystallisation from ethanol/water afforded the title compound as platelets (0.647 g.), m.p. 155.0° C.

Workup

  1. temperatureThe mixture was cooled
  2. extractionextracted into chloroform
  3. washthe chloroform extracts washed with water
  4. dry with materialdried (MgSO4)
  5. customevaporated
  6. customto give a white solid
  7. customRecrystallisation from ethanol/water

Sources & evidence

ORD record
ord-9d356a509a3d42e49cfaea50e67a49e6
Source dataset
uspto-grants-1976_10
Patent number
US03985898

Reaction notes

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