Potassium Carbonate → HCID 21506805, compound

Participants

Reaction Steps

A mixture of 4.0 g. of 1,3-dihydrospiro[isobenzofuran-1,4'-piperidine], 6.04 g. of α-chloro-p-fluorobutyrophenone ethylene ketal, 10 g. of potassium carbonate, and 50 ml. of 1-butanol is heated under reflux with stirring for 65 hours, cooled, and filtered. The filtrate is concentrated to an oil which is dissolved in 50 ml. of ethanol and 50 ml. of 3N hydrochloric acid. After 2 hours, the solution is made basic and extracted with benzene. Concentration of the benzene solution provides 1,3-dihydro1'-[3-(4-fluorobenzoyl)propyl]spiro[isobenzofuran-1,4'-piperidine]-3-one as an oil; hydrochloride salt, m.p. 183°-184°.

Provenance & Evidence