Thionyl Chloride → HCID 21506832, compound

HRID 1287899Notes

Reaction equation

HRID 1287899 reaction equation
[Cl:1][C:2]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:3]=1[C:4]([NH:6][C:7]([CH3:11])([CH3:10])[CH2:8][OH:9])=O.S(Cl)(Cl)=O>>[Cl:1][C:2]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:3]=1[C:4]1[O:9][CH2:8][C:7]([CH3:11])([CH3:10])[N:6]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 223362772-Chloro-4-fluoro-N-(1-hydroxy-2-methylpropan-2-yl)benzamide

Product 1

HCID 21506832HCID 21506832, compound

Procedure

Reaction of 2-chloro-4-fluoro-N-(1-hydroxy2-methyl-2-propyl)benzamide and thionyl chloride by the method described in Example 1b provides 2-(2-chloro-4-fluorophenyl)-4,4-dimethyl-2-oxazoline as a liquid; hydrochloride salt, m.p. 138°-139°.

Sources & evidence

ORD record
ord-9933ae2fcd8b43d98637e73017822420
Source dataset
uspto-grants-1976_10
Patent number
US03985889

Reaction notes

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