4-Hydroxybenzaldehyde → HCID 86749099, compound

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Reaction Steps

By the method of example 13 above, 4-hydroxybenzaldehyde (12.0 g) and (2E)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-butenol (Chem. Abstr., 94, 65904h) (20.5 g) are coupled with triphenylphosphine and diethyl azodicarboxylate to provide 4-((2E)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-butenyloxy)benzaldehyde (15.9 g, 50%) as a colorless oil after chromatography. By the method of example 2 above, this is converted into the title compound, mp 136°-137° after recrystallization from hexane-dichloromethane.

Provenance & Evidence