HCID 21506829, compound → HCID 21506816, compound

HRID 1287901Notes

Reaction equation

HRID 1287901 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:14](=[CH:15][C:16]=1[O:17][CH3:18])[C:8]1([CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[O:7][C:6]2=[O:19].C1O[C:23]([C:28]2[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=2)([CH:24](Cl)[CH2:25][CH3:26])[O:22]C1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:14](=[CH:15][C:16]=1[O:17][CH3:18])[C:8]1([CH2:13][CH2:12][N:11]([CH2:26][CH2:25][CH2:24][C:23](=[O:22])[C:28]3[CH:29]=[CH:30][C:31]([F:34])=[CH:32][CH:33]=3)[CH2:10][CH2:9]1)[O:7][C:6]2=[O:19]

Participants

3

Reactant 2

HCID 21506829HCID 21506829, compoundHCID 23193548HCID 23193548, compound

Product 1

HCID 21506816HCID 21506816, compound

Procedure

Reaction of 1,3-dihydro-5,6-dimethoxyspiro[isobenzofuran-1,4'-piperidine]-3-one and α-chloro-p-fluorobutyrophenone ethylene ketal by the method described in Example 6 provides 1,3-dihydro-5,6-dimethoxy-1'-[3-(4-fluorobenzoyl)propyl]spiro[isobenzofuran-1,4'-piperidine]-3-one.

Sources & evidence

ORD record
ord-0c3b57d76aeb40f1994394c316d1af18
Source dataset
uspto-grants-1976_10
Patent number
US03985889

Reaction notes

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