3H-spiro[2-benzofuran-1,4'-piperidine] → HCID 12213007, compound

HRID 1287909Notes

Reaction equation

HRID 1287909 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4]2([C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH2:8][O:7]2)[CH2:3][CH2:2]1.C1O[C:18]([C:23]2[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=2)([CH:19](Cl)[CH2:20][CH3:21])[O:17]C1>>[F:29][C:26]1[CH:25]=[CH:24][C:23]([C:18]([CH2:19][CH2:20][CH2:21][N:1]2[CH2:6][CH2:5][C:4]3([C:14]4[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=4)[CH2:8][O:7]3)[CH2:3][CH2:2]2)=[O:17])=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 104424983H-spiro[2-benzofuran-1,4'-piperidine]HCID 23193548HCID 23193548, compound

Product 1

HCID 12213007HCID 12213007, compound

Procedure

Reaction of 1,3-dihydrospiro[isobenzofuran1,4'-piperidine] and α-chloro-p-fluorobutyrophenone ethylene ketal by the method described in Example 6 provides 1,3-dihydro-1'-[3-(4-fluorobenzoyl)propyl]spiro[isobenzofuran-1,4'-piperidine] as a solid, hydrochloride salt, m.p. 215°-217°.

Sources & evidence

ORD record
ord-ef723c85ce1d4814ad00ce1528578ebb
Source dataset
uspto-grants-1976_10
Patent number
US03985889

Reaction notes

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