HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-4-piperidone → 4-Hydroxy-4-(alpha-hydroxy-4-trifluoromethyl-2-tolyl)-1-methylpiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-4-piperidone | HCID 74049 | — |
| Reactant | [2-Bromo-4-(trifluoromethyl)phenyl]methanol | HCID 2779289 | — |
| Product | 4-Hydroxy-4-(alpha-hydroxy-4-trifluoromethyl-2-tolyl)-1-methylpiperidine | HCID 86733526 | — |
Reaction Steps
Reaction of 2-bromo-4-trifluoromethylbenzyl alcohol and 1-methyl-4-piperidone by the method described in Example 16a provides 4-hydroxy-4-(α-hydroxy-4-trifluoromethyl-2-tolyl)-1-methylpiperidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03985889 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-3c22f7d026a343379cdd38be83d78bd0 |
| Source note | uspto-grants-1976_10 |