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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1287913Generated: October 30, 2026

Hydrochloric Acid → 1,3-Dihydro-1',5-dimethylspiro[isobenzofuran-1,4'-piperidine]

https://huagongshe.com/reaction/1287913

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 86733527HCID 86733527—
Product1,3-Dihydro-1',5-dimethylspiro[isobenzofuran-1,4'-piperidine]HCID 21506812—

Reaction Steps

Treatment of 4-hydroxy-4-(α-hydroxy-5-methyl-2-tolyl)-1-methylpiperidine with hydrochloric acid by the method described in Example 16d provides 1,3-dihydro-1',5-dimethylspiro[isobenzofuran-1,4'-piperidine].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03985889
Source datasetuspto-grants-1976_10
ORD IDord-0ce4b6ab1ad54542b382ee7c49934f85
Source noteuspto-grants-1976_10