HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1,3-Dihydro5-fluoro-1'-methylspiro[isobenzofuran-1,4'-piperidine]
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-(5-Fluoro-alpha-hydroxy-2-tolyl)-4-hydroxy-1-methylpiperidine | HCID 86733529 | — |
| Product | 1,3-Dihydro5-fluoro-1'-methylspiro[isobenzofuran-1,4'-piperidine] | HCID 21506822 | — |
Reaction Steps
Treatment of 4-(5-fluoro-α-hydroxy-2-tolyl)-4-hydroxy-1-methylpiperidine with hydrochloric acid by the method described in Example 16d provides 1,3-dihydro5-fluoro-1'-methylspiro[isobenzofuran-1,4'-piperidine].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03985889 |
| Source dataset | uspto-grants-1976_10 |
| ORD ID | ord-fce8ec83fe3149a6a16cdada47140453 |
| Source note | uspto-grants-1976_10 |