Thionyl Chloride → 4-(2-Cyanoethyl)benzoyl chloride

HRID 1287958Notes

Reaction equation

[C:1]([CH2:3][CH2:4][C:5]1[CH:13]=[CH:12][C:8]([C:9](O)=[O:10])=[CH:7][CH:6]=1)#[N:2].S(Cl)([Cl:16])=O>>[C:1]([CH2:3][CH2:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([Cl:16])=[O:10])=[CH:7][CH:6]=1)#[N:2]

Participants

Reactant 2

HCID 24386Thionyl Chloride2×

HCID 1987919655584-01-5

Product 1

HCID 450817144-(2-Cyanoethyl)benzoyl chloride

Procedure

A mixture of 17.5 parts of 4-(2-cyanoethyl) benzoic acid and 120 parts of thionyl chloride are refluxed for 15 minutes. The surplus thionyl chloride is then eliminated under reduced pressure and the 4-(2-cyanoethyl) benzoyl chloride is obtained which is liquid at atmospheric temperature.

Workup

temperatureare refluxed for 15 minutes

Sources & evidence

ORD record: ord-95030aba77e9410f92b623f38cd26edd
Source dataset: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03987027

Reaction notes

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