Hydrochloric Acid → HCID 21503366, compound

Participants

Reaction Steps

A solution of 10 g of 2-hydroxyethyl-quinuclidine in 80 ml of anhydrous chloroform was cooled to 0° C and treated with anhydrous gaseous hydrogen chloride. 50 ml of thionyl chloride were then added to the solution and the reaction mixture was heated to reflux for 3 hours. The excess thionyl chloride and the chloroform were removed by evaporation under reduced pressure on a water bath at 50° C. The residue was purified by washing with anhydrous ether. The ethereal suspension was filtered and the crystals obtained were dried under reduced pressure at room temperature. 12 g of 2-chloroethyl-quinuclidine, m.p. 202° C, were obtained.

Provenance & Evidence