Trifluoroacetic acid → 3-Methoxyiminomethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid

Participants

Reaction Steps

To a solution of diphenylmethyl-3-methoxyiminomethyl- 7-(2 -thienylacetamido)-3-cephem-4 -carboxylate (394 mg) in methylene chloride (11 ml) are added anisole (1.1 ml) and trifluoroacetic acid (1.1 ml) at 0° C under argon atmosphere, and the mixture is kept at the same temperature for 25 minutes, and at room temperature for 25 minutes. The reaction mixture is evaporated, and trituration of the residue in ether gives 3-methoxyiminomethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid (216 mg). m.p. 186°-189° C.

Provenance & Evidence