Sulfuric Acid → HCID 13195827, compound

HRID 1288011Notes

Reaction equation

HRID 1288011 reaction equation
[C:1]([C:9]1[C:10]([NH:24][CH:25]([CH2:27][CH3:28])[CH3:26])=[C:11]2[C:17](C)=[N:16][N:15](C3OC=CC=3)[C:12]2=[N:13][CH:14]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)O>>[C:1]([C:9]1[C:10]([NH:24][CH:25]([CH2:27][CH3:28])[CH3:26])=[C:11]2[CH:17]=[N:16][NH:15][C:12]2=[N:13][CH:14]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 131710505HCID 131710505, compound

Product 1

HCID 13195827HCID 13195827, compound

Procedure

3.7 g. of 5-benzoyl-4-sec.butylamino-1-(2-furanyl)-methyl-1H-pyrazolo[3,4-b]pyridine are stirred in 20 ml. of conc. sulfuric acid for 3 hours at 50°. The mixture is decomposed with 30 ml. of water and filtered. The filtrate is made alkaline with 30% aqueous ammonia and the white precipitate of 5-benzoyl-4-sec.butylamino-1H-pyrazolo[3,4-b]-pyridine is filtered off, yield 1.7 g. (58%), m.p. 186°-187°.

Workup

  1. filtrationof water and filtered
  2. filtrationthe white precipitate of 5-benzoyl-4-sec.butylamino-1H-pyrazolo[3,4-b]-pyridine is filtered off

Sources & evidence

ORD record
ord-d47dfd0795ac4954a06c438a11a8adb8
Source dataset
uspto-grants-1976_10
Patent number
US03987051

Reaction notes

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