1-Methyl-2-nitro-1H-imidazole-5-carboxaldehyde → 1-Methyl-5-[1-(2-hydroxyethyl)-5-ethyl-2-imidazolyl]iminomethyl-2-nitroimidazole

Participants

Reaction Steps

To a solution of 0.4 g. of 1-methyl-2-nitro-5-imidazolecarboxaldehyde dissolved in 25 ml. of ethanol, 0.494 g. of 1-(2-hydroxyethyl)-2-amino-5-ethylimidazole hydrochloride and 0.175 ml. of sodium ethoxide in 2.89 ml. of ethanol are added. After standing overnight, the solid which precipitates is collected on the filter and washed with water. Yield: 0.269 g., m.p. 185°-187° C.

Provenance & Evidence