反应详情

To a solution of 3.15 g. of 1-methyl-2-nitro-5-(1,2-dihydroxyethyl)imidazole in 200 ml. of methanol, a solution of 3.6 g. of NaIO4 in 85 ml. of water is added with stirring. The precipitate which forms is filtered off and washed with methanol which is then added to the filtrate. By evaporation to dryness under vacuum a residue is obtained which is extracted several times with ethyl acetate. After concentration of the collected extracts, a crystalline product is obtained, which after recrystallization from ethyl acetate melts at 114°-115° C. Yield 2.5 g. (96%).

1. filtrationThe precipitate which forms is filtered off
2. washwashed with methanol which
3. additionis then added to the filtrate
4. customBy evaporation to dryness under vacuum a residue
5. customis obtained which
6. extractionis extracted several times with ethyl acetate
7. customAfter concentration of the collected extracts, a crystalline product is obtained
8. customwhich after recrystallization from ethyl acetate melts at 114°-115° C