反应详情

To a solution of 0.67 g. of 1-methyl-2-nitro-5-vinylimidazole in 20 ml. of 1,2-dimethoxyethane, a solution of 2 g. of NaIO4 in 5 ml. of water, followed by 0.025 g. of OsO4 is added with stirring at room temperature. After stirring for four hours, the mixture is allowed to stand overnight. The residue which is obtained by evaporation of the reaction medium to dryness under vacuum is extracted with ethyl acetate. The resulting solution after filtering is concentrated, yielding 0.43 g. of a product which, after crystallization from ethyl acetate, melts at 114°-115° C. Yield 63%.

1. stirringAfter stirring for four hours
2. customThe residue which is obtained by evaporation of the reaction medium to dryness under vacuum
3. extractionis extracted with ethyl acetate
4. filtrationThe resulting solution after filtering
5. concentrationis concentrated
6. customyielding 0.43 g
7. customof a product which, after crystallization from ethyl acetate, melts at 114°-115° C