HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1288047Generated: October 25, 2026
2-Methylpropanehydrazide → 8-chloro-1-isopropyl-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine
https://huagongshe.com/reaction/1288047
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Methylpropanehydrazide | HCID 19239 | — |
| Reactant | Thionordiazepam | HCID 826706 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 8-chloro-1-isopropyl-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine | HCID 12560618 | — |
Reaction Steps
In the manner given in Example 2, 7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione is heated in ethanol with isobutyric acid hydrazide and the resulting product heated to 250° C. to give 8-chloro-1-isopropyl-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US03987052 |
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| Source dataset | uspto-grants-1976_10 |
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| ORD ID | ord-d76fb7e2ece14c96841b404f3f7a4841 |
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| Source note | uspto-grants-1976_10 |
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