Propionylhydrazine → 8-chloro-1-ethyl-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine

Participants

Reaction Conditions

Reaction Steps

In the manner given in Example 2, 7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione was heated in ethanol with propionic acid hydrazide and the resulting product heated to 250° C. to give 8-chloro-1-ethyl-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine of melting point 231.5°-232.5° C. The ultraviolet spectrum (ethanol) had end absorption λ max. 224 (ε = 39,250) and inflections 248 (ε = 15,000), 266 (ε = 6,900) and 290 mμ(ε = 3,250).

Provenance & Evidence