Acetohydrazide → HCID 21489336, compound

HRID 1288051Notes

Reaction equation

HRID 1288051 reaction equation
[CH2:1]([S:3][C:4]1[C:9]2[C:10]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[Br:22])=[N:11][CH2:12][C:13](=S)[NH:14][C:8]=2[CH:7]=[CH:6][CH:5]=1)[CH3:2].[C:23]([NH:26][NH2:27])(=O)[CH3:24]>C(O)C>[CH2:1]([S:3][C:4]1[C:9]2[C:10]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[Br:22])=[N:11][CH2:12][C:13]3[N:14]([C:23]([CH3:24])=[N:26][N:27]=3)[C:8]=2[CH:7]=[CH:6][CH:5]=1)[CH3:2]

Participants

4

Reactant 2

HCID 14039AcetohydrazideHCID 19865850HCID 19865850, compound

Product 1

HCID 21489336HCID 21489336, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
250 °C

Procedure

In the manner given in Example 2, 6-ethylthio-1,3-dihydro-5-(o-bromophenyl)-2H-1,4-benzodiazepine-2-thione is heated in ethanol with acetic acid hydrazide and the resulting product heated to 250° C. to give 7-ethylthio-1-methyl-6-(o-bromophenyl)4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-9f4c4b4d8ca149738af35eb1fb92b64f
Source dataset
uspto-grants-1976_10
Patent number
US03987052

Reaction notes

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