Hydrazinecarboxaldehyde → HCID 21489312, compound

HRID 1288052Notes

Reaction equation

HRID 1288052 reaction equation
[F:1][C:2]([F:27])([F:26])[C:3]1[C:13]2[NH:12][C:11](=S)[CH2:10][N:9]=[C:8]([C:15]3[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:25])[CH2:23][CH3:24])=[CH:17][CH:16]=3)[C:7]=2[CH:6]=[CH:5][CH:4]=1.[CH:28]([NH:30][NH2:31])=O>C(O)C>[F:1][C:2]([F:27])([F:26])[C:3]1[C:13]2[N:12]3[CH:28]=[N:30][N:31]=[C:11]3[CH2:10][N:9]=[C:8]([C:15]3[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:25])[CH2:23][CH3:24])=[CH:17][CH:16]=3)[C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 12229HydrazinecarboxaldehydeHCID 19865762HCID 19865762, compound

Product 1

HCID 21489312HCID 21489312, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
250 °C

Procedure

In the manner given in Example 2, 9-(trifluoromethyl)-1,3-dihydro-5-[p-(propionylamino)phenyl]-2H-1,4-benzodiazepine-2-thione is heated in ethanol with formic acid hydrazide and the resulting product heated to 250° C. to give 10-(trifluoromethyl)-6-[p-(propionylamino)pheyl]-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-675b913248134821ab9c9ef0da1ea892
Source dataset
uspto-grants-1976_10
Patent number
US03987052

Reaction notes

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