Benzeneacetic acid, hydrazide → HCID 21489339, compound

HRID 1288054Notes

Reaction equation

HRID 1288054 reaction equation
[CH2:1]([O:4][C:5]1[C:26]([Br:27])=[CH:25][C:8]2[C:9]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([S:21]([CH2:23][CH3:24])=[O:22])[CH:16]=3)=[N:10][CH2:11][C:12](=S)[NH:13][C:7]=2[CH:6]=1)[CH2:2][CH3:3].[C:28]1([CH2:34][C:35]([NH:37][NH2:38])=O)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>C(O)C>[CH2:1]([O:4][C:5]1[C:26]([Br:27])=[CH:25][C:8]2[C:9]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([S:21]([CH2:23][CH3:24])=[O:22])[CH:16]=3)=[N:10][CH2:11][C:12]3[N:13]([C:35]([CH2:34][C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)=[N:37][N:38]=3)[C:7]=2[CH:6]=1)[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 70301Benzeneacetic acid, hydrazideHCID 19865806HCID 19865806, compound

Product 1

HCID 21489339HCID 21489339, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
250 °C

Procedure

In the manner given in Example 2, 8-propoxy-7-bromo-1,3-dihydro-5-[m-(ethylsulfinyl)phenyl]-2H-1,4-benzodiazepine-2-thione is heated in ethanol with phenylacetic acid hydrazide and the resulting product heated to 250° C. to give 9-propoxy-8-bromo-1-benzyl-6-[ m-(ethylsulfinyl)phenyl]-4H-s-triazolo-[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-af55127d534f48938ad383c6f18ab920
Source dataset
uspto-grants-1976_10
Patent number
US03987052

Reaction notes

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