Butyrohydrazide → HCID 21489327, compound

HRID 1288055Notes

Reaction equation

HRID 1288055 reaction equation
[C:1]([C:3]1[CH:24]=[CH:23][C:6]2[C:7]([C:13]3[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=3)=[N:8][CH2:9][C:10](=S)[NH:11][C:5]=2[CH:4]=1)#[N:2].[C:25]([NH:30][NH2:31])(=O)[CH2:26][CH2:27][CH3:28]>C(O)C>[C:1]([C:3]1[CH:24]=[CH:23][C:6]2[C:7]([C:13]3[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=3)=[N:8][CH2:9][C:10]3[N:11]([C:25]([CH2:26][CH2:27][CH3:28])=[N:30][N:31]=3)[C:5]=2[CH:4]=1)#[N:2]

Participants

4

Reactant 2

HCID 77079ButyrohydrazideHCID 19865797HCID 19865797, compound

Product 1

HCID 21489327HCID 21489327, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
250 °C

Procedure

In the manner given in Example 2, 8-cyano-1,3-dihydro-5-[p-(trifluoromethyl)phenyl]-2H-1,4-benzodiazepine-2-thione is heated in ethanol with butyric acid hydrazide and the resulting product heated to 250° C. to give 9-cyano-1-propyl-6-[p-(trifluoromethyl)phenyl]-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-302b217b765c4f6fa4f1756e634c3fc6
Source dataset
uspto-grants-1976_10
Patent number
US03987052

Reaction notes

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