Acetohydrazide → HCID 21489328, compound

HRID 1288058Notes

Reaction equation

HRID 1288058 reaction equation
[CH3:1][CH:2]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[Cl:15])[C:6]2[C:16]([CH3:21])=[CH:17][C:18]([CH3:20])=[CH:19][C:5]=2[NH:4][C:3]1=S.[C:23]([NH:26][NH2:27])(=O)[CH3:24]>C(O)C>[CH3:24][C:23]1[N:4]2[C:5]3[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([CH3:21])[C:6]=3[C:7]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[Cl:15])=[N:8][CH:2]([CH3:1])[C:3]2=[N:27][N:26]=1

Participants

4

Reactant 2

HCID 14039AcetohydrazideHCID 21503716HCID 21503716, compound

Product 1

HCID 21489328HCID 21489328, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
250 °C

Procedure

In the manner given in Example 2, 3,6,8-trimethyl-1,3-dihydro-5-(o-chlorophenyl)- 2H-1,4-benzodiazepine-2-thione is heated in ethanol with acetic acid hydrazide and the resulting product heated to 250° C. to give 1,4,7,9-tetramethyl-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-034f5d0448fa41feaca2c32201702aa2
Source dataset
uspto-grants-1976_10
Patent number
US03987052

Reaction notes

Loading…