Hydrazinecarboxaldehyde → HCID 21489325, compound

HRID 1288060Notes

Reaction equation

HRID 1288060 reaction equation
[CH3:1][N:2]([CH3:21])[C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11](=S)[CH2:10][N:9]=[C:8]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:7]=2[CH:20]=1.[CH:22]([NH:24][NH2:25])=O>C(O)C>[CH3:1][N:2]([CH3:21])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]3[CH:22]=[N:24][N:25]=[C:11]3[CH2:10][N:9]=[C:8]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:7]=2[CH:20]=1

Participants

4

Reactant 2

HCID 12229HydrazinecarboxaldehydeHCID 19865768HCID 19865768, compound

Product 1

HCID 21489325HCID 21489325, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
250 °C

Procedure

In the manner given in Example 2, 7-(dimethylamino)-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione is heated in ethanol with formic acid hydrazide and the resulting product is heated to 250° C. to give 8-(dimethylamino)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-65a9fccd067a42abb346d8690464148a
Source dataset
uspto-grants-1976_10
Patent number
US03987052

Reaction notes

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