Acetohydrazide → HCID 21489321, compound

HRID 1288063Notes

Reaction equation

HRID 1288063 reaction equation
[N+:1]([C:4]1[C:9]2[C:10]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:22]#[N:23])=[N:11][CH2:12][C:13](=S)[NH:14][C:8]=2[CH:7]=[CH:6][CH:5]=1)([O-:3])=[O:2].[C:24]([NH:27][NH2:28])(=O)[CH3:25]>C(O)C>[N+:1]([C:4]1[C:9]2[C:10]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:22]#[N:23])=[N:11][CH2:12][C:13]3[N:14]([C:24]([CH3:25])=[N:27][N:28]=3)[C:8]=2[CH:7]=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 14039AcetohydrazideHCID 21503710HCID 21503710, compound

Product 1

HCID 21489321HCID 21489321, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
250 °C

Procedure

In the manner given in Example 2, 6-nitro-1,3-dihydro-5-(o-cyanophenyl)-2H-1,4-benzodiazepine-2-thione is heated in ethanol with acetic acid hydrazide and the resulting product heated to 250° C. to give 7-nitro-1-methyl-6-(o-cyanophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-5f39393eafc64fd384a4bb6031f2bd78
Source dataset
uspto-grants-1976_10
Patent number
US03987052

Reaction notes

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