Hydrazinecarboxaldehyde → HCID 21489318, compound

HRID 1288064Notes

Reaction equation

HRID 1288064 reaction equation
[CH2:1]([N:4]([CH2:26][CH2:27][CH3:28])[C:5]1[CH:6]=[CH:7][C:8]2[NH:14][C:13](=S)[CH2:12][N:11]=[C:10]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[N+:22]([O-:24])=[O:23])[C:9]=2[CH:25]=1)[CH2:2][CH3:3].[CH:29]([NH:31][NH2:32])=O>C(O)C>[CH2:1]([N:4]([CH2:26][CH2:27][CH3:28])[C:5]1[CH:6]=[CH:7][C:8]2[N:14]3[CH:29]=[N:31][N:32]=[C:13]3[CH2:12][N:11]=[C:10]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[N+:22]([O-:24])=[O:23])[C:9]=2[CH:25]=1)[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 12229HydrazinecarboxaldehydeHCID 21503708HCID 21503708, compound

Product 1

HCID 21489318HCID 21489318, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
250 °C

Procedure

In the manner given in Example 2, 7-(dipropylamino)-1,3-dihydro-5-(o-nitrophenyl)-2H-1,4-benzodiazepine-2-thione is heated in ethanol with formic acid hydrazide and the resulting product heated to 250° C. to give 8-(dipropylamino)-6-(o-nitrophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-a0ab234d4b5a454c86d49f62b37e4c32
Source dataset
uspto-grants-1976_10
Patent number
US03987052

Reaction notes

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