Propionylhydrazine → HCID 21489331, compound

HRID 1288065Notes

Reaction equation

HRID 1288065 reaction equation
[C:1]([NH:4][C:5]1[C:15]2[NH:14][C:13](=S)[CH2:12][N:11]=[C:10]([C:17]3[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][CH:18]=3)[C:9]=2[CH:8]=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[C:25]([NH:29][NH2:30])(=O)[CH2:26][CH3:27]>C(O)C>[C:1]([NH:4][C:5]1[C:15]2[N:14]3[C:25]([CH2:26][CH3:27])=[N:29][N:30]=[C:13]3[CH2:12][N:11]=[C:10]([C:17]3[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][CH:18]=3)[C:9]=2[CH:8]=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 79890PropionylhydrazineHCID 19865801HCID 19865801, compound

Product 1

HCID 21489331HCID 21489331, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
250 °C

Procedure

In the manner given in Example 2, 9-acetylamino-1,3-dihydro-5-(p-cyanophenyl)-2H-1,4-benzodiazepine-2-thione is heated in ethanol with propionic acid hydrazide and the resulting product heated to 250° C. to give 10-(acetylamino)-1-ethyl-6-(p-cyanophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-7d26f555843141a7befdae70e6fcf381
Source dataset
uspto-grants-1976_10
Patent number
US03987052

Reaction notes

Loading…