Isobutyl chloroformate → 4-Hydroxybenzophenone

Participants

Reaction Steps

Following the procedure of Example 1 but using 0.738 g. of PGF2α, 0.291 ml. of triethylamine, 0.275 ml. of isobutylchloroformate and 0.594 g. of p-hydroxybenzophenone, there is obtained a crude residue. This residue is subjected to silica gel chromatography, eluting with ethyl acetate-water (99:1). The residue obtained by concentration of selected fractions, 0.492 g., is crystallized from ethyl acetate diluted with three volumes of hexane as the title compound, white free-flowing crystals, m.p. 73.8°-75.8° C., having Rf 0.5 (TLC on silica gel in ethyl acetate).

Provenance & Evidence