Sodium Hydroxide → Tetrafluoro-m-phenylenediamine dihydrochloride

HRID 1288113Notes

Reaction equation

HRID 1288113 reaction equation
[OH-].[Na+].C([N:6]1[CH2:20][CH2:19][C:18]2[C:9](=[N:10][C:11]3[C:12]([NH2:22])=[CH:13][CH:14]=[CH:15][C:16]=3[C:17]=2[CH3:21])[CH2:8][CH2:7]1)(=O)C.[C:23]1([NH2:34])[C:28]([F:29])=[C:27]([F:30])[C:26]([F:31])=[C:25]([NH2:32])[C:24]=1[F:33].[ClH:35].Cl>>[NH2:22][C:12]1[C:11]2[N:10]=[C:9]3[CH2:8][CH2:7][NH:6][CH2:20][CH2:19][C:18]3=[C:17]([CH3:21])[C:16]=2[CH:15]=[CH:14][CH:13]=1.[C:23]1([NH2:34])[C:28]([F:29])=[C:27]([F:30])[C:26]([F:31])=[C:25]([NH2:32])[C:24]=1[F:33].[ClH:35].[ClH:35]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 149026Tetrafluoro-m-phenylenediamine dihydrochloride2×HCID 21503448HCID 21503448, compound

Product 2

HCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 21503437HCID 21503437, compound

Procedure

7-Amino-1,2,4,5-tetrahydro-11-methyl-3H-azepino[4,5-b]quinoline and its dihydrochloride were prepared by hydrolysis with 2 N sodium hydroxide of 3-acetyl-7-amino-1,2,4,5-tetrahydro-11-methyl-3H-azepino[4,5-b]quinoline, and subsequent conversion of the base into its dihydrochloride. Yield of the dihydrochloride: 83%; of theory; m.p. 285° C. (decomp.).

Sources & evidence

ORD record
ord-05cc97efade5494ba7de7a26e86e2c5b
Source dataset
uspto-grants-1976_10
Patent number
US03987047

Reaction notes

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