Ethyl chloroformate → 3H-Azepino(4,5-b)quinoline-3-carboxylic acid, 1,2,4,5-tetrahydro-11-methyl-, ethyl ester

HRID 1288116Notes

Reaction equation

C([N:3]1[CH2:17][CH2:16][C:15]2[C:6](=[N:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[C:14]=2[CH3:18])[CH2:5][CH2:4]1)C.Cl[C:20]([O:22][CH2:23][CH3:24])=[O:21]>>[CH2:23]([O:22][C:20]([N:3]1[CH2:17][CH2:16][C:15]2[C:6](=[N:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[C:14]=2[CH3:18])[CH2:5][CH2:4]1)=[O:21])[CH3:24]

Participants

Reactant 2

HCID 10928Ethyl chloroformate

HCID 3044005HCID 3044005, compound

Product 1

HCID 30440083H-Azepino(4,5-b)quinoline-3-carboxylic acid, 1,2,4,5-tetrahydro-11-methyl-, ethyl esterYield 10%

Procedure

1,2,4,5-Tetrahydro-11-methyl-3-azepino[4,5-b]quinoline-carboxylic acid ethyl ester was prepared from 3-ethyl-1,2,4,5-tetrahydro 11-methyl-3H-azepino[4,5-b]quinoline and ethyl chloroformate analogous to Example 59.

Sources & evidence

ORD record: ord-90bc7b0bd21a4f47ba4bced4da5e9cfc
Source dataset: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03987047

Reaction notes

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