Ethyl chloroformate → HCID 68140407, compound

HRID 1288124Notes

Reaction equation

[CH3:1][O:2][C:3]1[C:12]2[N:11]=[C:10]3[CH2:13][CH2:14][NH:15][CH2:16][CH2:17][C:9]3=[C:8]([CH3:18])[C:7]=2[CH:6]=[CH:5][CH:4]=1.[Cl:19][C:20]([O:22][CH2:23][CH3:24])=[O:21]>>[ClH:19].[CH2:23]([O:22][C:20]([N:15]1[CH2:16][CH2:17][C:9]2[C:10](=[N:11][C:12]3[C:3]([O:2][CH3:1])=[CH:4][CH:5]=[CH:6][C:7]=3[C:8]=2[CH3:18])[CH2:13][CH2:14]1)=[O:21])[CH3:24]

Participants

Reactant 2

HCID 10928Ethyl chloroformate

HCID 21503453HCID 21503453, compound

Product 1

HCID 68140407HCID 68140407, compoundYield 49%

Procedure

1,2,4,5-Tetrahydro-7-methoxy-11-methyl-3-azepino[4,5-b]quinoline-carboxylic acid ethyl ester hydrochloride was prepared from 1,2,4,5-tetrahydro-7-methoxy-11-methyl-3H-azepino[4,5-b]quinoline and ethyl chloroformate analogous to Example 63.

Sources & evidence

ORD record: ord-43226caff2d04bed8cde75a64fc3429b
Source dataset: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03987047

Reaction notes

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