Ethyl chloroformate → HCID 68139326, compound

HRID 1288126Notes

Reaction equation

[Br:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[C:7]3[CH2:12][CH2:13][NH:14][CH2:15][CH2:16][C:6]3=[C:5]([CH3:17])[C:4]=2[CH:3]=1.[Cl:18][C:19]([O:21][CH2:22][CH3:23])=[O:20]>>[ClH:18].[CH2:22]([O:21][C:19]([N:14]1[CH2:15][CH2:16][C:6]2[C:7](=[N:8][C:9]3[CH:10]=[CH:11][C:2]([Br:1])=[CH:3][C:4]=3[C:5]=2[CH3:17])[CH2:12][CH2:13]1)=[O:20])[CH3:23]

Participants

Reactant 2

HCID 10928Ethyl chloroformate

HCID 21503566HCID 21503566, compound

Product 1

HCID 68139326HCID 68139326, compoundYield 62%

Procedure

9-Bromo-1,2,4,5-tetrahydro-11-methyl-3-azepino[4,5-b]quinoline-carboxylic acid ethyl ester hydrochloride was prepared from 9-bromo-1,2,4,5-tetrahydro-11-methyl- 3H-azepino[4,5-b]quinoline and ethyl chloroformate analogous to Example 63.

Sources & evidence

ORD record: ord-d27bf1322d754f6a8112c8ff56459281
Source dataset: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03987047

Reaction notes

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