Ethyl chloroformate → HCID 68140223, compound

HRID 1288129Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[N:9]=[C:8]3[CH2:13][CH2:14][NH:15][CH2:16][CH2:17][C:7]3=[C:6]([CH3:18])[C:5]=2[CH:4]=1.[Cl:19][C:20]([O:22][CH2:23][CH3:24])=[O:21]>>[ClH:19].[CH2:23]([O:22][C:20]([N:15]1[CH2:16][CH2:17][C:7]2[C:8](=[N:9][C:10]3[CH:11]=[CH:12][C:3]([O:2][CH3:1])=[CH:4][C:5]=3[C:6]=2[CH3:18])[CH2:13][CH2:14]1)=[O:21])[CH3:24]

Participants

Reactant 2

HCID 10928Ethyl chloroformate

HCID 21503605HCID 21503605, compound

Product 1

HCID 68140223HCID 68140223, compoundYield 66%

Procedure

1,2,4,5-Tetrahydro-9-methoxy-11-methyl-3-azepino[4,5-b]quinoline-carboxylic acid ethyl ester hydrochloride was prepared from 1,2,4,5-tetrahydro-9-methoxy-11-methyl-3H-azepino[4,5-b]quinoline and ethyl chloroformate analogous to Example 63.

Sources & evidence

ORD record: ord-8560373545184eb59559e7f4c5c6a0df
Source dataset: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03987047

Reaction notes

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