Ethyl chloroformate → HCID 68140303, compound

HRID 1288138Notes

Reaction equation

[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[C:7]3[CH2:12][CH2:13][CH2:14][NH:15][CH2:16][C:6]3=[C:5]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:4]=2[CH:3]=1.Cl[C:24]([O:26][CH2:27][CH3:28])=[O:25]>>[ClH:1].[CH2:27]([O:26][C:24]([N:15]1[CH2:14][CH2:13][CH2:12][C:7]2=[N:8][C:9]3[CH:10]=[CH:11][C:2]([Cl:1])=[CH:3][C:4]=3[C:5]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[C:6]2[CH2:16]1)=[O:25])[CH3:28]

Participants

Reactant 2

HCID 10928Ethyl chloroformate

HCID 21503423HCID 21503423, compound

Product 1

HCID 68140303HCID 68140303, compoundYield 89%

Procedure

9-Chloro-2,3,4,5-tetrahydro-11-phenyl-1H-2-azepino[4,3-b]quinoline-carboxylic acid ethyl ester hydrochloride was prepared from 9-chloro-2,3,4,5-tetrahydro-11-phenyl-1H-azepino[4,3-b]quinoline and ethyl chloroformate analogous to Example 63.

Sources & evidence

ORD record: ord-4484c6c20533409889421cdeb86c8813
Source dataset: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03987047

Reaction notes

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