Phenyl chloroformate → HCID 54436714, compound

HRID 1288139Notes

Reaction equation

HRID 1288139 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:3].C([N:13]1[CH2:27][CH2:26][C:25]2[C:16](=[N:17][C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:23]=3[C:24]=2[Cl:28])[CH2:15][CH2:14]1)C>C(Cl)Cl.CCOCC>[C:5]1([O:4][C:2]([N:13]2[CH2:27][CH2:26][C:25]3[C:16](=[N:17][C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][C:23]=4[C:24]=3[Cl:28])[CH2:15][CH2:14]2)=[O:3])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

5

Reactant 2

HCID 15891Phenyl chloroformateHCID 21503394HCID 21503394, compound

Product 1

HCID 54436714HCID 54436714, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent2×

Procedure

A solution of 1.2 gm (7.7 millimols) of phenyl chloroformate in 20 ml of methylene chloride was added dropwise to a mixture of 2 gm (7.7 millimols) of 3-ethyl-11-chloro-1,2,4,5-tetrahydro-3H-azepino[4,5-b]quinoline and 15 ml of methylene chloride at 5° C. After standing overnight, the resulting mixture was diluted with ether to double its volume and was then suction-filtered. The filter cake was recrystallized from acetone.

Workup

  1. filtrationwas then suction-filtered
  2. customThe filter cake was recrystallized from acetone

Sources & evidence

ORD record
ord-afbe12c6fca34ecea2cab8d7c203fa90
Source dataset
uspto-grants-1976_10
Patent number
US03987047

Reaction notes

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