Ethyl chloroformate → 11-chloro-3-ethoxycarbonyl-1,2,4,5-tetrahydro-3H-azepino[4,5-b]quinoline

HRID 1288140Notes

Reaction equation

HRID 1288140 reaction equation
C([N:8]1[CH2:22][CH2:21][C:20]2[C:11](=[N:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=3[C:19]=2[Cl:23])[CH2:10][CH2:9]1)C1C=CC=CC=1.Cl[C:25]([O:27][CH2:28][CH3:29])=[O:26]>>[CH2:28]([O:27][C:25]([N:8]1[CH2:22][CH2:21][C:20]2[C:11](=[N:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=3[C:19]=2[Cl:23])[CH2:10][CH2:9]1)=[O:26])[CH3:29]

Participants

3

Reactant 2

HCID 10928Ethyl chloroformateHCID 21503407HCID 21503407, compound

Product 1

HCID 2150364411-chloro-3-ethoxycarbonyl-1,2,4,5-tetrahydro-3H-azepino[4,5-b]quinolineYield 97%

Procedure

11-Chloro-1,2,4,5-tetrahydro-3-azepino[4,5-b]quinoline-carboxylic acid ethyl ester was prepared analogous to Example 98 from 3-benzyl-11-chloro-1,2,4,5-tetrahydro-3H-azepino[4,5-b]quinoline and ethyl chloroformate.

Sources & evidence

ORD record
ord-56d34f3762824688bbcd0f1644d80b06
Source dataset
uspto-grants-1976_10
Patent number
US03987047

Reaction notes

Loading…