Phenyl chloroformate → HCID 178524303, compound

HRID 1288143Notes

Reaction equation

C([N:8]1[CH2:23][CH2:22][CH2:21][C:11]2=[N:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=3[C:19]([OH:20])=[C:10]2[CH2:9]1)C1C=CC=CC=1.Cl[C:25]([O:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:26]>>[C:28]1([O:27][C:25]([N:8]2[CH2:23][CH2:22][CH2:21][C:11]3=[N:12][C:13]4[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=4[C:19]([OH:20])=[C:10]3[CH2:9]2)=[O:26])[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Participants

Reactant 2

HCID 15891Phenyl chloroformate

HCID 178515156HCID 178515156, compound

Product 1

HCID 178524303HCID 178524303, compoundYield 51%

Procedure

11-Hydroxy-2,3,4,5-tetrahydro-1H-2-azepino[4,3-b]quinoline-carboxylic acid phenyl ester was prepared analogous to Example 101 from 2-benzyl-11-hydroxy-2,3,4,5-tetrahydro-1H-azepino[4,3-b]quinoline and phenyl chloroformate.

Sources & evidence

ORD record: ord-f4da514e41c045cfac4ed0a6a1bbefb0
Source dataset: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03987047

Reaction notes

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