HuagongsheHuagongshe Chemistry Print Report · For research reference only
Indole-3-Butyric Acid → 4-(2-oxo-2,3-dihydro-1H-indol-3-yl)butanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Indole-3-Butyric Acid | HCID 8617 | — |
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | DMSO HCl | HCID 12206146 | — |
| Product | 4-(2-oxo-2,3-dihydro-1H-indol-3-yl)butanoic acid | HCID 2764088 | 89% |
Reaction Steps
Similar treatment of methyl 3-(3-indolinyl)propanoic [II: R1 =R3 =H, R2 =(CH2)2COOH] (0.93 g) with DMSO/HCl, followed by esterification with diazomethane and chromatography on silica gel, gave methyl 3-(2-oxo-3-indolyl)propanoate [III: R1 -R3 =H, R2 =(CH2)2COOMe] (0.89 g, 89%) as a yellow oil (Julian P. L., Printy H. C., J. Am. Chem. Soc. 1953;75:5301-5305 report mp 79°-80° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05464861 |
| Source dataset | uspto-grants-1995_11 |
| ORD ID | ord-781cb543a31145bb87d9dd9617e30235 |
| Source note | uspto-grants-1995_11 |