Dimethylamine → HCID 68140352, compound

HRID 1288170Notes

Reaction equation

[CH2:1]([O:3][C:4]([N:6]1[CH2:20][CH2:19][C:18]2[C:9](=[N:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=3[C:17]=2[CH3:21])[CH:8]([Cl:22])[CH2:7]1)=[O:5])[CH3:2].[CH3:23][NH:24][CH3:25]>>[ClH:22].[ClH:22].[CH2:1]([O:3][C:4]([N:6]1[CH2:20][CH2:19][C:18]2[C:9](=[N:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=3[C:17]=2[CH3:21])[CH:8]([N:24]([CH3:25])[CH3:23])[CH2:7]1)=[O:5])[CH3:2]

Participants

Reactant 2

HCID 674Dimethylamine

HCID 54025343HCID 54025343, compound

Product 1

HCID 68140352HCID 68140352, compoundYield 77%

Procedure

5-Dimethylamino-1,2,4,5-tetrahydro-11-methyl-3-azepino[4,5-b]quinoline-carboxylic acid ethyl ester dihydrochloride was prepared from 5-chloro-1,2,4,5-tetrahydro-11-methyl-3-azepino[4,5-b]quinoline-carboxylic acid ethyl ester and dimethylamine analogous to Example 173.

Sources & evidence

ORD record: ord-6fbd92f3fd904a7e891f2bb6c8f2d78e
Source dataset: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03987047

Reaction notes

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